The absorption occurs in the small intestine by passive diffusion. Nitrofurans suction from the distal segment of the small intestine than absorption from the proximal and mid segments, respectively, in 2 and 4 times (to be taken into account while treating urogenital infections and gastrointestinal diseases, including chronic enteritis). Nitrofurans poorly absorbed in the colon.
, being a mixture furazyadina potassium and magnesium hydroxycarbonate in the ratio 1: 1, in oral administration has a higher bioavailability than simple furazidin (after taking capsules tri tren 250 in the acidic environment of the stomach does not occur transformation potassium furazidina in poorly soluble furazidin).
In the body furazidin evenly distributed. Clinically, it is important to the high content of the active substance anabolic z store in the lymph (delay spread lymphatic infection). The bile concentration in several times higher than in blood serum and tri tren 250 times less than in serum. Saliva furazidina content is 30% of the serum concentration. Furazidina concentration in blood and tissues is relatively small, due to its rapid release, when the concentration in urine is considerably higher than in the blood. Maximum concentration in the blood is stored for 3 to 7 or 8 hours furazidin detected in the urine 3-4 hours after application.
Unlike nitrofurantoin (furadonina), after acceptance urine pH changes. After 4 hours after taking furazidina urine concentration significantly higher than the concentration that is formed after administration of the same dose Furagin medicament. Isolation takes place through the kidneys by glomerular filtration and tubular secretion (85%), partially exposed tubule reabsorption back. At low concentrations furazidina filtering process and secretion dominates in the urine at high concentrations and reduced secretion increased reabsorption.Furazidin, being a weak acid, in an acidic urine does not dissociate under intense reabsorption, which may enhance the development of systemic side effects. At tri tren 250 alkalization of urine excretion furazidina increases. The active drug substance is slightly biotransformed (less than 10% of the administered dose), with a decrease in renal excretory function of the intensity of metabolism increases.
Infections caused by microorganisms sensitive to furazidinu: urogenital infections (acute cystitis, urethritis, pyelonephritis), skin and soft tissue infections, severe infected burns, gynecological infections. Oseltamivir can be used in urologic surgery, cystoscopy, catheterization, and others.
Hypersensitivity to the drug nitrofuran group, pregnancy and lactation. Severe chronic renal failure. Children under 3 years of age (for a given dosage form).
Precautions: shortage of glucose-6-phosphate dehydrogenase.
Dosage and administration.
The drug is taken after meals, drinking plenty tri tren 250 of fluids. Adults appoint 50-100 mg (2-4 capsules) 3 times daily. Children appoint 25-50 mg (1-2 capsules) 3 times a day but not more than 5 mg / kg body weight per day. The course of treatment is from 7-10 days. If necessary, after a 10-15 day break, repeat the course. To prevent infections in urologic operations, cystoscopy, catheterization and other drug prescribed:. Adult at 50 mg once daily for 30 minutes before the procedure; children to 25 mg once daily for 30 minutes before the procedure. If you forget to take your next dose, take the next dose at the usual time. Do not take a double dose to replace the missed dose.
In case of overdose symptoms observed neurotoxic nature, ataxia and tremor.
In case of poisoning should drink plenty of fluids. For the relief of acute symptoms used antihistamines. To prevent neuritis possible appointment of vitamins (thiamine bromide).
Rarely observed are typical of other nitrofurans side effects:. Headache, dizziness, nausea, vomiting, loss of appetite, polyneuritis, liver function abnormalities, allergic reactions (skin rash, papular rash)
If during treatment Ftri tren 250 showed side effects not listed in instructions, you should inform your doctor.
Effects on ability to drive a vehicle were observed.
Drug interactions. Simultaneously with ristomycin, chloramphenicol, sulfonamides (the risk of depression increases hematopoiesis).
During treatment, it is desirable to refrain from drinking alcoholic beverages, as may worsen the side effects.
It is not recommended to tri tren 250 simultaneously nitrofurans prescribe drugs that can “acidified” urine (including ascorbic acid, calcium chloride).