Absorption from the gastrointestinal tract – good. Bioavailability – 50% (food increases the bioavailability). The rate of absorption depends on the crystal size (microcrystalline form is characterized by rapid dissolution and absorption rate, a short time in reaching Cmax urine). Connection with the plasma protein-60%.
It is metabolized in the liver and muscle tissue. The what is trenabolminutes. It penetrates through the placenta, the blood-brain barrier, excreted in breast milk. Displays fully kidneys (30-50% – unchanged).
Bacterial urinary tract infections (pyelitis, pyelonephritis, cystitis, urethritis), prevention of infections in urologic surgery or examination .
Hypersensitivity, chronic renal failure, chronic heart failure II-III century., Cirrhosis, chronic hepatitis B, deficiency of glucose-6-phosphate dehydrogenase, acute porphyria, pregnancy, lactation, children’s age (up to 1 month).
Nausea, vomiting, allergic reactions (lupus-like syndrome, arthralgia, myalgia, anaphylaxis, fever, eosinophilia, rash), dizziness, headache, fatigue, nystagmus, drowsiness, interstitial changes what is trenabol in the lungs, bronchial obstruction, fever, cough, sore chest, cyanosis, hepatitis, cholestatic syndrome, peripheral neuropathy, optic neuritis, pancreatitis, pseudomembranous enterocolitis, rare – abdominal pain, diarrhea.
Symptoms: vomiting. Treatment: drinking large amounts of fluid leads to increased excretion of the drug in the urine. Effective dialysis.
The interaction with other drugs.
The simultaneous use of nalidixic acid and an antacid comprising magnesium trisilicate, reduces antibacterial effect. Incompatible with fluoroquinolones. Drugs that block tubular secretion, reduced antibacterial what is trenabol effect (by reducing the concentration of nitrofurantoin urine) and increase the toxicity (increased blood concentration) of the drug.